4.7 Article

Nucleophilic trifluoromethylation of imines using the CF3I/TDAE reagent

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 70, Issue 12, Pages 4741-4745

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/jo050483v

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The nucleophilic trifluoromethylation reagent derived from CF3I and tetrakis(dimethylamino)ethylene (TDAE) was found to be effective in addition to both N-tosyl aldimines and N-tolyl sulfinimines, the latter reaction exhibiting very good diastereoselectivity.

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