4.4 Article

Direct and indirect reductive amination of aldehydes and ketones with solid acid-activated sodium borohydride under solvent-free conditions

Journal

TETRAHEDRON
Volume 61, Issue 24, Pages 5725-5734

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.04.039

Keywords

reductive amination; imines; reductions; solvent-free reaction; sodium borohydride

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A simple and convenient procedure for reductive amination of aldehydes and ketones using sodium borohydride activated by boric acid, p-toluenesulfonic acid monohydrate or benzoic acid as reducing agent under solvent-free conditions is described. (c) 2005 Elsevier Ltd. All rights reserved.

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