Journal
MOLECULAR BRAIN RESEARCH
Volume 137, Issue 1-2, Pages 263-266Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbrainres.2005.02.029
Keywords
BLT1 receptor; leukotriene B-4; dorsal root ganglion neuron; intracellular Ca2+
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We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene 134 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B-4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B-4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons. (c) 2005 Elsevier B.V. All rights reserved.
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