Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 24, Pages 8686-8691Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0500419102
Keywords
cytokine; nflammation; macrophage
Categories
Funding
- NCI NIH HHS [P30 CA 21765, P30 CA021765] Funding Source: Medline
- NIAID NIH HHS [AI062921, R01 AI062921] Funding Source: Medline
Ask authors/readers for more resources
The anti inflammatory cytokine IL-10 inhibits the production of multiple, diverse inflammatory mediators from activated macrophages and dendritic cells, a process requiring STAT3 activation. However, the mechanisms involved in the broad inhibitory effects of IL-10 are controversial. I eliminated the contribution of the major confounding variable to understanding the antiinflammatory response, the 3' UTR region of inflammatory mediator genes, through knock-in mutation and analysis of the effects of IL-10 on transcription rate of inflammatory genes. IL-10 activates STAT3 to act indirectly by selectively inhibiting gene transcription independent of general effects on NF-kappa B or posttranscriptional mRNA processing through a process that reduces the overall transcriptional rate of specific genes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available