Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 24, Pages 8662-8667Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0503360102
Keywords
apoptosis; cytokine; antigen-presenting cells; memory phenotype CD8 T cell
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The survival of CD8(+)/CD44(hi) memory phenotype T cells depends on an IL-15 activity on nonlymphoid cells. Here, we report that IL-15 and its receptor were induced on dendritic cells (DCs) by a combination of IFN-gamma and NF-kappa B relA inducers. IL-15 conferred in an autocrine loop resistance to apoptosis that accompanied the maturation process in DCs in vitro. As an apparent result in vivo, mice deficient in IL-15 or its receptor harbor few DCs. Injecting DCs into IL-15(-/-) mice was associated with the appearance of CD8(+)/CD44(hi) T cells that depended on IL-15 expression but also correlated with the longevity of the DCs. These findings support the hypothesis that DCs mediate the effect of IL-15 on CD8(+)/CD44(hi) memory phenotype T cells.
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