Journal
PEDIATRIC BLOOD & CANCER
Volume 44, Issue 7, Pages 630-637Publisher
WILEY
DOI: 10.1002/pbc.20346
Keywords
anthracycline cardiac pathology; coronary artery disease; radiation cardiac pathology; radiation valvular disease
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Radiation-induced heart disease (RIHD) and anthracycline cardiotoxicity are two patterns of cardiac dysfunction caused by therapeutic interventions to treat malignancies. They occur in both the pediatric and adult populations and there is evidence to suggest that pediatric patients are at greater risk. This is due in part to the longer survival rates but also reflects increased susceptibility to the attendant complications caused by both therapies. Radiation can cause injury to all the components of the heart, including the vasculature, while anthracycline toxicity is generally limited to the myocardium. (c) 2005 Wiley-Liss, Inc.
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