Journal
TALANTA
Volume 66, Issue 5, Pages 1168-1174Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.talanta.2005.01.021
Keywords
standard addition methodology; uncertainty; metal chelates; liquid chromatography
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If a matrix effect is detected during the validation stage of an analytical method, the standard addition methodology must be applied. To reach a good estimation of the uncertainty associated with the determination, an adequate identification and evaluation of each uncertainty source should be done. As an example to illustrate how to calculate the uncertainty in this case, the simultaneous determination of V(V) and Mo(VI) at trace levels after precolumn chelation and extraction with N-benzoyl-N-phenylhydroxylamine, has been selected. The final results show that the main contributions to the relative overall uncertainty are those closely related with the chemical aspects of the method, i.e. liquid-liquid extraction and standard addition calibration. (c) 2005 Elsevier B.V. All rights reserved.
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