Journal
DRUG DISCOVERY TODAY
Volume 10, Issue 12, Pages 823-837Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(05)03458-6
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Funding
- NIDA NIH HHS [P30 DA018310] Funding Source: Medline
- NIDDK NIH HHS [R33 DK070285] Funding Source: Medline
- NINDS NIH HHS [R01 NS031609] Funding Source: Medline
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Imaging mass spectrometry (IMS) encompasses a variety of techniques that enable the chemical imaging of analytes, which range in size from atoms and small molecules to intact proteins, directly from biological tissues. IMS is transforming specific areas in biological research with its unique combination of chemical and spatial information. Innovations in instrumentation and imaging protocols will make this approach invaluable at many stages of the drug discovery process, including pharmacological target screening and evaluating the distribution of drug and drug metabolites in cells and tissues. The fundamentals and unique methodology of IMS are discussed, along with exciting new applications to drug discovery science.
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