Journal
JOURNAL OF THE NEUROLOGICAL SCIENCES
Volume 233, Issue 1-2, Pages 87-91Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jns.2005.03.008
Keywords
remyelination; multiple sclerosis; oligodendrocyte precursor cell; transcription factor; growth factor; inflammation
Categories
Funding
- Multiple Sclerosis Society [689] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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There are two components to the treatment of multiple sclerosis (MS); the first is to prevent damage occurring, and the second is to repair the residual damage. While considerable progress has been made in the recent years with the former through the development of anti-inflammatory and immunomodulatory therapies, there are currently no effective repair therapies routinely used in MS patients. This represents a significant gap in the MS clinician's therapeutic armoury. In this article we argue that a clear understanding of the repair mechanisms following CNS demyclination is fundamental to filling this gap. We discuss (1) the cellular events involved in remyelination, (2) changes in transcription factor expression within oligodendrocyte precursor cells associated with their activation in response to demyelination, (3) the role of platelet derived growth factor in the OPC recruitment phase of remyelination, and (4) the significance of the inflammatory response associated with demyelination in creating a signalling environment that favours remyelination. (c) 2005 Elsevier B.V. All rights reserved.
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