Journal
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 15, Issue 12, Pages 3034-3038Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2005.04.031
Keywords
calpain; peptidomimetic; library diketopiperazine
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Funding
- NIGMS NIH HHS [P50-GM069663] Funding Source: Medline
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A small library of 2,5-diketopiperazines based on previously reported calpain inhibitors was synthesized. In addition, a concise total synthesis of the structurally related natural product phevalin (2) was accomplished. Despite literature reports that some of the compounds prepared were calpain inhibitors, none of the library members were found to have significant activity against recombinant human calpain 1. (c) 2005 Elsevier Ltd. All rights reserved.
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