Journal
LANCET
Volume 365, Issue 9477, Pages 2122-2124Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/S0140-6736(05)66735-9
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Funding
- NCI NIH HHS [CA-82481] Funding Source: Medline
- NHLBI NIH HHS [HL-63766, F32-HL-71407] Funding Source: Medline
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Tissue engineering has made considerable progress in the past decade, but advances have stopped short of clinical application for most tissues. We postulated that an obstacle in engineering human tissues is the limited replicative capacity of adult somatic cells. To test this hypothesis, the effectiveness of telomerase expression to extend cellular lifespan was assessed in a model of human vascular tissue engineering. Telomerase expression in vascular cells isolated from elderly patients enabled the successful culture of engineered autologous blood vessels. Engineered vessels may one day provide a source of bypass conduit for patients with atherosclerotic disease.
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