Journal
RETROVIROLOGY
Volume 2, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1742-4690-2-40
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Funding
- NIAID NIH HHS [R01 AI036199] Funding Source: Medline
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TRIM5 is a potent retrovirus inhibitor that targets viruses bearing particular capsid ( CA) residues. In most primate species, retroviral restriction requires the C-terminal SPRY domain unique to the alpha-isoform of TRIM5, but the mechanism by which susceptible viruses are recognized and targeted for restriction is unknown. Here we show that TRIM5 alpha binds retroviral CA from detergent-stripped virions in a SPRY-dependent manner with sufficient discrimination to account for the exquisite specificity of restriction.
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