Journal
NEUROREPORT
Volume 16, Issue 9, Pages 1013-1016Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200506210-00026
Keywords
drug cues; metabotropic glutamate receptors; opiate self-administration; reinstatement; relapse
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In humans, drug-associated stimuli can provoke heroin relapse during abstinence. In rats, cues paired with heroin self-administration reinstate heroin seeking in a relapse model. The neurobiological mechanisms involved in this reinstatement, however, are largely unknown. Here, we determined the effect of LY379268, an mGluR(2/3) agonist that decreases evoked glutamate release, on cue-induced reinstatement of heroin seeking. Systemic injections of LY379268 attenuated reinstatement of heroin seeking induced by exposure to a discrete tone-light cue that was previously paired with heroin infusions during self-administration training. In contrast, LY379268 had no effect on heroin self-administration. Results indicate that glutamate plays an important role in cue-induced reinstatement of heroin seeking and suggest that mGluR(2/3) agonists should be considered for the treatment of opiate relapse. (c) 2005 Lippincott Williams & Wilkins.
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