Journal
ANALYTICA CHIMICA ACTA
Volume 542, Issue 1, Pages 14-19Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aca.2004.12.019
Keywords
molecularly imprinted polymers; solid-phase extraction; cocaine; cocaine metabolites; benzoylecgonine
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Cocaine is a well-known drug of abuse which, when ingested nasally or by smoking, undergoes a number of biotransformation and degradation reactions. In the present work, a synthetic analogue of the cocaine metabolite benzoylecgonine was prepared and used as a template molecule in the preparation of a series of molecularly imprinted polymers (MIPs). Molecularly imprinted solid-phase extraction (MISPE) conditions were established under which benzoylecgonine in aqueous samples could be selectively extracted and quantified at clinically relevant concentrations (mu g/ml). Under optimised MISPE conditions, recoveries of analyte were high (> 70%) and excellent discrimination between imprinted and non-imprinted materials observed. (c) 2004 Elsevier B.V. All rights reserved.
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