Model systems for flavoenzyme activity: Site-isolated redox behavior in flavin-functionalized random polystyrene copolymers

A model system has been developed to study the redox behaviors of flavin derivatives appended onto random polystyrene copolymers through click chemistry strategies. The results demonstrate that flavin units attached onto polymers exhibit site-isolated redox behaviors, yielding new materials with electrochemically tunable associations (K(a)(ox) = 450 M(-1), k(a)(red) = 18 200 M(-1)) to complementary diamiclopyridine (DAP) functionality.