Journal
NEUROSCIENCE LETTERS
Volume 381, Issue 3, Pages 234-236Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.02.029
Keywords
Niemann-Pick Type C disease; microglia; astroglia; inflammation; bone marrow-derived mesenchymal stem cell; transplantation
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Glial activation is thought to play a key role in pathogenesis of neurodegenerative disorders. Here we show, that direct transplantation of bone marrow-derived mesenchymal stem cells (BM-MSC) results in alleviation of inflammatory responses associated with the cerebellum of Niemann-Pick disease Type C (NP-C) model mice. Immunohistochemical examinations using glial fibrillary acidic protein (GFAP) and F4/80 antibodies revealed that BM-MSC transplantation reduced significantly both of astocytic and microglial activations in the cerebellum of NP-C mice. Expression of macrophage colony stimulating factor (M-CSF), a microglial activator, was also considerably down-regulated by the BM-MSC transplantation. These findings suggest that BM-MSC transplantation may have potential for a therapeutic role in the treatment of NP-C and other neurodegenerative brain disorders. (c) 2005 Published by Elsevier Ireland Ltd.
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