Journal
TETRAHEDRON LETTERS
Volume 46, Issue 26, Pages 4461-4464Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2005.04.096
Keywords
phase-transfer catalysis; Michael addition; amino acids
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Funding
- Engineering and Physical Sciences Research Council [GR/S86129/01] Funding Source: researchfish
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The asymmetric Michael addition of glycine imine esters to simple alpha, beta-unsaturated ketones via PTC is investigated. It is found that by employing 1 mol % of a chiral quaternary ammonium salt, derived from alpha-methylnaphthylamine in conjunction with CS2CO3, high enantioselectivities can be obtained in conjugate additions involving simple alkylvinylketones. (c) 2005 Elsevier Ltd. All rights reserved.
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