Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 102, Issue 26, Pages 9294-9299Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0503596102
Keywords
CD81; Huh-7; viral entry; viral spread; interferon
Categories
Funding
- NCI NIH HHS [R01 CA108304, CA108304] Funding Source: Medline
- NIAID NIH HHS [R21 AI060391, AI060391, R21 AI060391-02] Funding Source: Medline
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The absence of a robust cell culture model of hepatitis C virus (HCV) infection has severely limited analysis of the HCV life cycle and the development of effective antivirals and vaccines. Here we report the establishment of a simple yet robust HCV cell culture infection system based on the HCV JFH-1 molecular clone and Huh-7-derived cell lines that allows the production of virus that can be efficiently propagated in tissue culture. This system provides a powerful tool for the analysis of host-virus interactions that should facilitate the discovery of antiviral drugs and vaccines for this important human pathogen.
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