Journal
BRAIN RESEARCH
Volume 1048, Issue 1-2, Pages 116-122Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2005.04.087
Keywords
xenografts; stem cells; cerebral ischemia; graft survival; motor behavior; neurological deficits
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Funding
- NINDS NIH HHS [R21NS043487-02] Funding Source: Medline
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We examined the effects of timing and routes of transplantation on survival and functional benefits of human bone-marrow-derived CD133+ cells in experimentally stroke Sprague-Dawley rats. At day 7 post-stroke, both immediate and delayed intracerebral transplantation resulted in similar graft survival (7%) that was localized within the original transplant site and reduction of motor (27%) and neurological (40%) deficits. In contrast, graft survival (0.0 1 -0.04%) was only detected in delayed intravenous transplantation, characterized by cell migration throughout the ipsilateral stroke hemisphere. Behavioral improvement, however, was limited to neurological response and only apparent in immediate intravenous transplantation. Reduction of cerebral infarct (25%) was only noted in intracerebral transplantation. Intravenous transplantation requires optimization for improved therapeutic outcome of CD 133+ cell grafts in stroke. Crown Copyright (c) 2005 Published by Elsevier B.V. All rights reserved.
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