Journal
REGULATORY PEPTIDES
Volume 128, Issue 3, Pages 211-220Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.regpep.2004.12.011
Keywords
Na+/H+ exchanger; angiotensin II; endothelin; NPCa2+ exchanger
Categories
Ask authors/readers for more resources
The stretch of adult papillary muscle elicits a chain of autocrine/paracrine events in which the Na+/H+ exchanger (NHE-1) activation is the central step. This activation is induced by a sequential angiotensin II-endothelin (Ang II-ET) release and results in an increase in intracellular Na+ (Na-i(+)) without significant changes in intracellular pH. The increase in Nai+ negatively shifts the reverse potential of the Na+/Ca2+ exchanger (NCX) thus inducing cell Ca2+ influx that augments myocardial contractility. This increase in force represents the mechanical counterpart of the autocrine/paracrine mechanism triggered by stretch and has been called the slow force response (SFR) to stretch. (c) 2004 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available