Journal
EXPERIMENTAL PARASITOLOGY
Volume 110, Issue 3, Pages 265-269Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.exppara.2005.02.023
Keywords
RNAi, RNA interference; siRNA; small interfering RNA; dsRNA, double strand RNA; Gal4AD, Gal4 activation domain; Gal4l3D. Ga14 DNA binding domain; Entamoeba histolytica; RNase III; AGO2; RNA interference
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Entamoeba histolytica, a protozoan parasite with variable DNA content and complex ploidity, has defied most efforts aimed at gene depletion using classical genetic methods. In this study, we identified and characterized two proteins involved in the RNA interference (RNAi) pathway, RNase III and AGO2. Our results strengthen the findings that an RNAi pathway does exist in this parasite. (c) 2005 Elsevier Inc. All rights reserved.
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