Journal
BIOPHYSICAL JOURNAL
Volume 89, Issue 1, Pages 87-94Publisher
BIOPHYSICAL SOCIETY
DOI: 10.1529/biophysj.104.048280
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The mechanical coupling of a cell with the extracellular matrix relies on adhesion sites, clusters of membrane-associated proteins that communicate forces generated along the F-Actin. laments of the cytoskeleton to connecting tissue. Nascent adhesion sites have been shown to regulate these forces in response to tissue rigidity. Force-regulation by substrate rigidity of adhesion sites with fixed area is not possible for stationary adhesion sites, according to elasticity theory. A simple model is presented to describe force regulation by dynamical adhesion sites.
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