Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 84, Issue 1, Pages 25-32Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2005.03.002
Keywords
learning; memory; extinction; short-term memory; long-term memory; hippocampus; AP5; NMDA; anisomycin; protein synthesis
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Both the acquisition and the extinction of memories leave short- and long-term mnemonic traces. Here, we show that in male Wistar rats, the short-term memory for a step-down inhibitory avoidance task (IA) is resistant to extinction, and that its expression does not influence retrieval or extinction of long-term memory. It has been known for some time that short- and long-term inhibitory avoidance memory involve separate and parallel processes. Here we show that, instead, short-term extinction of IA long-term memory is the first step towards its long-term extinction, and that this link requires functional NMDA receptors and protein synthesis in the CAI region of the dorsal hippocampus at the time of the first CS-no US presentation. (c) 2005 Elsevier Inc. All rights reserved.
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