Journal
DEVELOPMENTAL CELL
Volume 9, Issue 1, Pages 75-86Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2005.04.003
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Funding
- NEI NIH HHS [R01 EY011307, EY11307, R01 EY016805] Funding Source: Medline
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Coordinated microtubule and microfilament changes are essential for the morphological development of neurons; however, little is know about the underlying molecular machinery linking these two cytoskeletal systems. Similarly, the indispensable role of Rho-GTPase family proteins has been demonstrated, but it is unknown how their activities are specifically regulated in different neurites. In this paper, we show that the cytoplasmic dynein light chain Tctex-1 plays a key role in multiple steps of hippocampal neuron development, including initial neurite sprouting, axon specification, and later dendritic elaboration. The neuritogenic effects elicited by Tctex-1 are independent from its cargo adaptor role for dynein motor transport. Finally, our data suggest that the selective high level of Tctex-1 at the growth cone of growing axons drives fast neurite extension by modulating actin dynamics and also Rac1 activity.
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