Journal
DRUG DISCOVERY TODAY
Volume 10, Issue 13, Pages 895-907Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1359-6446(05)03484-7
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It has long been recognized that knowledge of the 3D structures of proteins has the potential to accelerate drug discovery, but recent developments in genome sequencing, robotics and bioinformatics have radically transformed the opportunities. Many new protein targets have been identified from genome analyses and studied by X-ray analysis or NMR spectroscopy. Structural biology has been instrumental in directing not only lead optimization and target identification, where it has well-established roles, but also lead discovery, now that high-throughput methods of structure determination can provide powerful approches to screening.
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