Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 12, Issue 7, Pages 626-627Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb957
Keywords
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Funding
- NIGMS NIH HHS [GM0822414, GM50313, GM0822415] Funding Source: Medline
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Despite the biological importance of self-splicing group II introns, little is known about their structural organization. Synthetic incorporation of site-specific photo-cross-linkers within catalytic domains resulted in functional distance constraints that, when combined with known tertiary interactions, provide a three-dimensional view of the active intron architecture. All functionalities important for both steps of splicing are proximal before the first step, suggestive of a single active-site region for group II intron catalysis.
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