4.7 Article

Does resistance to pyrazinamide accurately indicate the presence of Mycobacterium bovis?

Journal

JOURNAL OF CLINICAL MICROBIOLOGY
Volume 43, Issue 7, Pages 3530-3532

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/JCM.43.7.3530-3532.2005

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Funding

  1. FIC NIH HHS [K01 TW000001, K01 TW000001-06, TW 06083-01, K01 TW006083] Funding Source: Medline
  2. NIAID NIH HHS [AI 34238, R01 AI034238] Funding Source: Medline

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Mycobacterium bovis is best identified by screening those isolates of the Mycobacterium tuberculosis complex that have any pyrazinamide-(PZA) resistance, using a confirmatory test such as spoligotyping, biochemical testing, or genomic deletion analysis. The sensitivity for detection of M. bovis is lowered to 82% when only PZA-monoresistant isolates are screened.

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