Journal
VACCINE
Volume 23, Issue 31, Pages 4062-4069Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.vaccine.2004.11.076
Keywords
Taenia solium; therapeutic vaccine; protection; pig cysticercosis
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The S3Pvac synthetic vaccine composed of three peptides (GK1. KETc1 and KETc12) effectively protect against pig cysticercosis. Preliminary results point to an additional cysticidal capacity induced by S3Pvac or GK1 immunization, Herein. clear evidences of the cysticidal effect of S3Pvac but not of GK1 are presented. S3Pvac immunization of already experimentally infected pigs induced a reduction in the parasite load, in the vesicular cysticerci and in their viability. It also substantially increases the percent of histological damaged cysticerci more importantly in muscles than in brains. with a concomitant reduction in the antibody levels, Thus. S3Pvac represents a powerful means of controlling cysticercosis infection in pigs. (c) 2005 Published by Elsevier Ltd.
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