Journal
NATURE IMMUNOLOGY
Volume 6, Issue 7, Pages 722-729Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1213
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Funding
- NCI NIH HHS [CA107527, CA43059] Funding Source: Medline
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Cancer immunoediting' is a process wherein the immune system protects hosts against tumor development and facilitates outgrowth of tumors with reduced immunogenicity. Although interferon-gamma (IFN-gamma) is known to be involved in this process, the involvement of type 1 interferons (IFN-alpha/beta) has not been elucidated. We now show that, like IFN-gamma, endogenously produced IFN-alpha/beta was required for the prevention of the growth of primary carcinogen-induced and transplantable tumors. Although tumor cells are important IFN-gamma targets, they are not functionally relevant sites of the actions of the type 1 interferons. Instead, host hematopoietic cells are critical IFN-alpha/beta targets during development of protective antitumor responses. Therefore, type 1 interferons are important components of the cancer immunoediting process and function in a way that does not completely overlap the functions of IFN-gamma.
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