Journal
FEBS JOURNAL
Volume 272, Issue 14, Pages 3491-3504Publisher
WILEY
DOI: 10.1111/j.1742-4658.2005.04763.x
Keywords
cAMP; C-RAF; B-RAF; ERK; PKA; crosstalk
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One of the hallmarks of cAMP is its ability to inhibit proliferation in many cell types, but stimulate proliferation in others. Clearly cAMP has cell type specific effects and the outcome on proliferation is largely attributed to crosstalk from cAMP to the RAS/RAF/mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK pathway. We review the crosstalk between these two ancient and conserved pathways, describing the molecular mechanisms underlying the interactions between these pathways and discussing their possible biological importance.
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