Journal
INORGANICA CHIMICA ACTA
Volume 358, Issue 11, Pages 3183-3189Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.ica.2005.04.010
Keywords
cytotoxicity; ferrocene; pyrazole; chemotherapy
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The redox-active ferrocenoyl modified pyrazole ligand (3-Fc-AMP) readily coordinates to a variety of transition metal ions. Here, we describe our findings regarding the synthesis and structural characterization of iron and cobalt complexes of Fc-AMP, and the cytotoxicity profiles of these chemicals in vitro. Using the human mammary adenocarcinoma MCF-7 cell line we show that the free ligand and three metal complexes induced cytotoxicity with calculated LC(50)s ranging from 45.8 to 73.2 mu M. The toxicity of the complexes decreased as the redox potential increased. The present study demonstrates the potential chemotherapeutic promise of metal complexes of a redox-active ferrocenoyl modified pyrazole ligand on human cancer cells. (c) 2005 Elsevier B.V. All rights reserved.
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