Journal
JOURNAL OF LEUKOCYTE BIOLOGY
Volume 78, Issue 1, Pages 80-84Publisher
WILEY
DOI: 10.1189/jlb.1104669
Keywords
B cells; humoral immunity; mouse; innate immunity; knockout
Categories
Funding
- NIAID NIH HHS [AI60924] Funding Source: Medline
- PHS HHS [A096691] Funding Source: Medline
Ask authors/readers for more resources
It has been demonstrated previously that platelet-derived CD154 communicates with the adaptive immune compartment, enhancing B and T cell responses in CD154(-/-) mice. The presence of platelets was also shown to be necessary for optimal production of immunoglobulin G (IgG) in normal C57BL/6 mice. These data led us to hypothesize that platelets perform a sentinel function, quickly relaying activating signals to the adaptive immune compartment. Here, we report that platelet-deirived CD154 increases serum IgG levels and germinal center formation under conditions where antigen-specific CD4(+) T cell numbers are limiting. We propose that in the physiologic setting where antigen-specific B and T cells are rare, platelets function to enhance signals required for robust adaptive Immoral immunity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available