Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 33, Issue 3, Pages 114-119Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00003677-200507000-00003
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The concentration of plasma interleukin-6 (IL-6) increases during physical exercise, but until recently the cellular origin of this increase has been unknown. Recent work has identified that skeletal muscle is a major source of this increase and the release of IL-6 from muscle can mediate metabolic processes. IL-6 is, therefore, the first identified myokine released from muscle that can now be termed an endocrine organ.
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