Journal
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
Volume 20, Issue 7, Pages 988-994Publisher
WILEY
DOI: 10.1111/j.1440-1746.2005.03807.x
Keywords
anticancerous mechanism; cell cycle; gene expression; gastrointestinal cancer; histone deacetylase inhibitor
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Histone acetylation regulates gene transcription. Histone acetylation is a reversible process: histone acetyltransferases (HAT) transfer the acetyl moiety from acetyl coenzyme A to the lysine, and histone deacetylases (HDAC) remove the acetyl groups re-establishing the positive charge in the histones. HDAC inhibitors have antiproliferative activity against human cancer cells via cell cycle arrest, pro-differentiation, and pro-apoptosis. In recent years, many studies have shown that specific HDAC inhibitors are helpful for gastrointestinal cancer therapy. (C) 2005 Blackwell Publishing Asia Pty Ltd.
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