Journal
JOURNAL OF IMMUNOLOGY
Volume 175, Issue 1, Pages 32-36Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.175.1.32
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CD4(+) CD25(+) FoxP3(+) regulatory T cells (T-reg) suppress T cell function and protect rodents from autoimmune disease. Regulation of T-reg during an immune response is of major importance. Enhanced survival of T-reg is beneficial inautoimmunedisease, where as increased depletion by apoptosis is advantageous in cancer. We show here that freshly isolated FACS-sorted T-reg are highly sensitive toward CD95-mediated apoptosis, whereas other T cell populations are resistant to CD95-induced apoptosis shortly after isolation. In contrast, TCR restimulation of T-reg in vitro reg revealed a reduced sensitivity toward activation-induced cell death compared with CD4(+) CD25(-)T cells. Thus, the apoptosis phenotype of T is unique in comparison to reg other T cells, and this might be further explored for novel therapeutic modulations of Treg.
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