Journal
NEUROSCIENCE LETTERS
Volume 382, Issue 1-2, Pages 175-178Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2005.03.008
Keywords
Brn-2; neocortex; interaction protein; Jab1; neurodegenerative diseases
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Brain-2 (Brn-2), a Class III POU transcription factor, plays an important role in the development of the neocortex and the establishment of neural cell lineage. Here we performed a yeast two-hybrid screening to identify the Brn-2 binding proteins. We obtained Jun-activation-domain-binding protein 1 (Jab 1) as a new Brn-2 binding protein. Direct interaction between Brn-2 and Jab 1 was confirmed by using a surface plasmon resonance biosensor. Considering the involvement of Jab 1 in the onset of the neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease, the interaction between Brn-2 and Jab 1 may provide some insights into the understanding of neuronal development and neurodegenerative diseases. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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