Journal
NUTRITION REVIEWS
Volume 63, Issue 7, Pages 225-232Publisher
OXFORD UNIV PRESS INC
DOI: 10.1301/nr.2005.jul.225-232
Keywords
vitamin D; preeclampsia; pregnancy; prevention
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Funding
- Department of Health [PHCS/C4/4/016] Funding Source: Medline
- National Institute for Health Research [PHCS/C4/4/016] Funding Source: researchfish
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Preeclampsia has been suggested to result from a partial breakdown of tolerance to the developing fetus after maternal immune maladaptation. Several of the proposed immunomodulatory properties of the hormonal vitamin D system could potentially have beneficial effects for successful maintenance of pregnancy. Preeclampsia is characterized by marked changes in vitamin D metabolism. This paper reviews the evidence suggesting that the immunomodulatory properties of 1, 25(OH)(2)D may play a key role in maintaining immunological tolerance in pregnancy, and proposes that ensuring adequate vitamin D status/intake may help in the prevention and management of preeclampsia.
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