Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 53, Issue 7, Pages 829-831Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.829
Keywords
5-hydroxyzerumbone; zerumboneoxide; Zingiber zerumbet; nitric oxide production
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A new humulene sesquiterpene, 5-hydroxyzerumbone (5-hydroxy-2E,6E,9E-humulatrien-8-one) (1) and a known compound, zerumboneoxide (2) were isolated from the rhizomes of Zingiber zerumbet (Zingiberaceae), and found to inhibit lipopolysaccharide-induced nitric oxide production in murine macrophage RAW 264.7 cells with IC50 values of 14.1 and 23.5,mu m, respectively, by bioassay-guided fractionation (positive control: Amonomethyl-L-arginine, IC50,=21.3 mu m). The structure of I was determined by spectroscopic methods including 1D and 2D-NMR.
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