Journal
EXPERIMENTAL NEUROLOGY
Volume 194, Issue 1, Pages 43-56Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2005.01.012
Keywords
status epilepticus mRNA expression; receptor binding; H-3 receptor isoforms
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In rat thalamus, histamine H-1 receptor and isoforms of H-3 receptor were expressed predominantly in the midline and intralaminar areas. Correspondingly, higher H-1 and H-3 receptor binding was also detected in these areas. All isoforms of H-3 receptor were expressed in several thalamic nuclei, but there were minor differences between their expression patterns. H-1 mRNA expression was high in the ventral thalamus, but the H-1 binding level was low in these areas. Since increased brain histamine appears to have an antiepileptic effect through the H-1 receptor activity, kainic acid (KA)-induced status epilepticus in rat was used to study modulation of H-1 and H3 receptors in the thalamus following seizures. After systemic KA administration, transient decreases in mRNA expression of 14, receptor and H-3 receptor isoforms with full-length third intracellular loops were seen in the midline areas and the H-1 receptor mRNA expression also decreased in the ventral thalamus. After 1 week, a robust increase in mRNA expression of H-3 receptor isoforms with a full-length third intracellular loop was found in the ventral posterior, posterior, and geniculate nuclei. The changes indicate a modulatory role of H-3 receptor in the sensory and motor relays, and might be involved in possible neuroprotective and compensatory mechanisms after KA administration. However, short-term increases in the H-3 receptor binding appeared earlier (72 h) than the increases of H-3 mRNA expression (1-4 w). The elevations in H-3 binding were evident in the intralaminar area, laterodorsal, lateral posterior, posterior and geniculate nuclei, and were likely to be related to the cortical and subcortical inputs to thalamus. (c) 2005 Elsevier Inc. All rights reserved.
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