Journal
PURE AND APPLIED CHEMISTRY
Volume 77, Issue 7, Pages 1269-1276Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/pac200577071269
Keywords
asymmetric iodocyclization; chiral Lewis acids; chiral Lewis bases; enantioselective mercuriocyclization; 4-(2-naphthyl)bisoxazoline
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Asymmetric iodocyclization and mercuriocyclization of gamma-hydroxy-cis-alkenes have been established. The iodocyclization has been attained with 1.2 equiv of iodine in the presence of the catalyst system prepared from 0.3 equiv of (R,R)-salen-Co(II) complex and 0.75 equiv of NCS to produce 2-substituted tetrahydrofurans with up to 90% ee. The mercuriocyclization has been achieved using 1.2 equiv of Hg(II) complexed with 4-(2-naphthyl)bisoxazoline (1:1 complex) in the presence of 5 equiv of K2CO3 and 10 equiv of MeOH to procure 2-substituted tetrahydrofurans with up to 95% ee.
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