Journal
DEVELOPMENTAL BIOLOGY
Volume 283, Issue 1, Pages 29-39Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2005.03.037
Keywords
hematopoiesis; stem cells; patterning; fetal liver; bone marrow; spatial diversity
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Funding
- NCI NIH HHS [CA46592] Funding Source: Medline
- NIAMS NIH HHS [AR20557, 1 P30 AR48310] Funding Source: Medline
- NICHD NIH HHS [R21 HD40760-02] Funding Source: Medline
- NIDDK NIH HHS [DK58771] Funding Source: Medline
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Most tissues are patterned so that progenitors in different locations are programmed to have different properties. Stem cells from different regions of the nervous system acquire intrinsic differences in their properties as they migrate through distinct environments. Hematopoietic stem cells (HSCs) also migrate through diverse environments throughout life, raising the question of whether HSCs also acquire at least transient changes in their properties as they are exposed to diverse environments. Although we observed significant differences in hematopoiesis between the fetal liver and fetal spleen, we were not able to detect phenotypic, functional, or gene expression differences between the HSCs in these organs. Regional differences in definitive hematopoiesis are therefore not determined by regional differences between HSCs. We were also not able to detect phenotypic, functional, or gene expression differences between HSCs in different adult bone marrow compartments. Our failure to detect differences among stem cells from different regions of the hematopoietic system at the same time during development suggests that the hematopoietic system has evolved mechanisms to prevent the spatial reprogramming of HSC properties as they migrate between distinct environments. (C) 2005 Elsevier Inc. All rights reserved.
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