Journal
PROTEIN AND PEPTIDE LETTERS
Volume 12, Issue 5, Pages 465-471Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929866054395383
Keywords
standard mechanism inhibitors; scaffolding; serine proteinases; inhibitor stabilily
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Funding
- NIGMS NIH HHS [GM63539, GM10831] Funding Source: Medline
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In single domain, standard mechanism protein inhibitors of serine proteinases, about a dozen residues make contact with the cognate enzyme. The remainder of the molecule, the scaffolding, holds the reactive site region of the inhibitor in a canonical conformation, improves the binding by about six orders of magnitude and protects it from proteolysis. However, the stability and global structure of the scaffolding is irrelevant to inhibition, provided that inhibition is measured much below the melting temperature, T-m.
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