Journal
NATURE REVIEWS CANCER
Volume 5, Issue 7, Pages 573-580Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc1651
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As the signalling pathways that control cellular proliferation and death are unravelled, a range of targets have emerged as candidates for molecular cancer therapy. For their survival, cancer cells depend on a few highly activated signalling pathways; inhibition of these pathways has a strong apoptotic effect and can lead to tumour regression. But drugs that exploit this weakness, such as imatinib, have not cured patients: withdrawal of the drug leads to disease recurrence, and sustained treatment leads to the emergence of drug- resistant clones. Can cancer be cured, or will it have to be controlled as a chronic disease?
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