Journal
JOURNAL OF VIROLOGY
Volume 79, Issue 14, Pages 9320-9324Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.14.9320-9324.2005
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Funding
- NCI NIH HHS [F32 CA 0936328] Funding Source: Medline
- NIAID NIH HHS [R01 AI42257, P01 AI042257] Funding Source: Medline
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Interferon production and apoptosis in virus-infected cells are necessary to prevent progeny virus production and to eliminate infected cells. Paramyxovirus infection induces apoptosis through interferon regulatory factor 3 (IRF-3), but the exact mechanism of how IRF-3 functions is unknown. We show that IRF-3 is involved in the transcriptional induction of TRAIL, a key player in the apoptosis pathway. IRF-3 upregulates TRAIL transcription following viral infection and binds an interferon-stimulated response element in the TRAIL promoter. The mRNA for TRAIL and its receptor, DR5, are induced following viral infection. These studies identify TRAIL as a novel IRF-3 transcriptional target.
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