Journal
LEUKEMIA RESEARCH
Volume 29, Issue 7, Pages 803-812Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.leukres.2004.11.020
Keywords
Wt1; hematopoiesis; mouse; leukemia; transplantation; stem cells
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WT1 has been implicated in human leukemia and hematopoiesis, but its role in stem cell differentiation is not yet fully defined. We show that Wt1-null murine fetal liver cells are capable of reconstituting functional hematopoiesis following transplantation into irradiated recipients. There was also no significant difference between the in vitro colony-forming ability of wild-type and Wt1-null cells. Using a reporter gene assay in a transgenic mouse system, expression from the WT1 promoter was detectable in adult bone marrow, but undetectable in subsets of different hematopoietic cells. We conclude that WO is not essential for murine hematopoiesis and that there may be significant differences in its role between mouse and man. (c) 2005 Elsevier Ltd. All rights reserved.
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