Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 69, Issue 7, Pages 1300-1305Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.69.1300
Keywords
anti-ulcer drug; astaxanthin; gastric mucosal injury; orogastric administration; Xanthophyllomyces dendrorhous
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Ethanol has been found to induce ulcerative gastric lesion in humans. The present study investigated the in vivo protective effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant against ethanol-induced gastric mucosal injury in rats. The rats were treated with 80% ethanol for 3d after pretreatment with two doses of astaxanthin (5 and 25 mg/kg of body weight respectively) for 3d, while the control rats received only 80% ethanol for 3d. The oral administration of astaxanthin (5 and 25 mg/kg of body weight) showed significant protection against ethanol-induced gastric lesion and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment with astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin.
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