Journal
EUROPEAN JOURNAL OF IMMUNOLOGY
Volume 35, Issue 7, Pages 2157-2162Publisher
WILEY
DOI: 10.1002/eji.200526168
Keywords
CTLA-4; CD4(+)CD25(+); T cell; single nucleotide polymorphism
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Funding
- NIDA NIH HHS [R01-DA13324] Funding Source: Medline
- NIDDK NIH HHS [R01-DK56415] Funding Source: Medline
- NINDS NIH HHS [R01-NS39435] Funding Source: Medline
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A common single nucleotide polymorphism in CTLA4 has been linked with susceptibility and outcome in autoimmune and infectious diseases, respectively. Here, we show that this polymorphism is associated with the frequency of CD4(+)CD25(+) regulatory T cells in healthy human volunteers. We further show that, on a per cell basis, such regulatory T cells appear to be functionally indistinguishable across CTLA4 genotypes. These data implicate CTLA4 in regulatory T cell development, and provide a mechanism to account for the link between polymorphisms at this locus and the biological outcome of adaptive immune responses to self and to pathogens.
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