Journal
JOURNAL OF NEUROSCIENCE RESEARCH
Volume 81, Issue 1, Pages 102-109Publisher
WILEY
DOI: 10.1002/jnr.20542
Keywords
hearing; auditory; ablation; neurotransmitter
Categories
Funding
- NIDCD NIH HHS [P30 DC005188, P30 DC005188-01A19003, R01 DC000383, F32 DC000479-01, P30 DC05188, F32 DC000479-02, F32 DC000479, R01 DC000383-12] Funding Source: Medline
- NIGMS NIH HHS [F31 GM013553-05, 1F32GM013553, F31 GM013553] Funding Source: Medline
- PHS HHS [00383] Funding Source: Medline
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There is increasing evidence of activity-related plasticity in auditory pathways. The present study examined the effects of decreased activity on immunolocalization of the inhibitory neurotransmitter glycine in the cochlear nucleus of the rat after bilateral cochlear ablation. Specifically, glycine-immunoreactive puncta adjacent to somatic profiles were compared in normal hearing animals and animals deafened for 14 days. The number of glycine-immunoreactive puncta surrounding somatic profiles of spherical and globular bushy cells, glycine-immunoreactive type I stellate multipolar cells, radiate neurons (type II stellate multipolar cells), and fusiform cells decreased significantly. In addition, the number of glycine immunopositive tuberculoventral (vertical or corn) cells in the deep layer of the dorsal cochlear nucleus also decreased significantly. These results suggest that decreased inhibition reported in cochlear nucleus after deafness may be due to decreases in glycine. (c) 2005 Wiley-Liss, Inc.
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