Journal
EXPERIMENTAL NEUROLOGY
Volume 194, Issue 1, Pages 212-220Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.expneurol.2005.02.010
Keywords
local field potential; multi-unit activity; subthalamic nucleus; Parkinson's disease; synchronization; beta activity
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Depth recordings in patients with Parkinson's disease (PD) have demonstrated prominent oscillatory activity in the beta frequency (13 - 35 Hz) band in local field potentials (LFPs) recorded from the region of the subthalamic nucleus (STN). Although this activity has been hypothesized to contribute to bradykinesia, it is unclear to what extent the LFP oscillations arise in the STN and are synchronous with local neuronal discharge. We therefore recorded both LFPs and multi-neuronal activity from microelectrodes inserted into STN in six PD patients (9 sides) during functional neurosurgery. As microelectrodes passed from above STN into STN. there was a pronounced increase in beta frequency band LFP activity. Furthermore, spike-triggered averages of UP activity suggested that the discharges, of neurons in STN were locked to beta oscillations in the UP. The UP is therefore likely to represent synchronous activity in populations of neurons in the STN of patients with PD. (c) 2005 Elsevier Inc. All rights reserved.
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