Journal
NATURE IMMUNOLOGY
Volume 6, Issue 7, Pages 698-706Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1212
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Funding
- NIAID NIH HHS [AI46566, R21 AI046566, R01 AI046566] Funding Source: Medline
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One unresolved issue in gut immunity is how mucosal T lymphocytes are activated and which antigen-presenting cell (APC) is critical for the regulation of this process. We have identified a unique population of APCs that is exclusively localized in the lamina propria. These APCs constitutively expressed the costimulatory molecule CD70 and had antigen-presenting functions. After oral infection of mice with Listeria monocytogenes, proliferation and differentiation of antigen-specific T cells occurred in the gut mucosa in situ and blockade of CD70 costimulation abrogated the mucosal T cell proliferation and effector functions. Thus, a potent CD70-dependent stimulation via specialized tissue-specific APCs is required for the proliferation and differentiation of gut mucosal T cells after oral infection.
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